August 15, 2014: Dr. Jorge Castillo, Bing Center for Waldenstrom’s Macroglobulinemia presented his latest analysis of survival trends in WM at the 8th International Workshop on WM and Symposium on Multiple Myeloma (IWWM-8). His findings were as follows: Based on current knowledge, it was unclear if the prognosis of patients with Waldenström’s Macroglobulinemia was improving. Two recent studies from Europe provided disparate results. On one hand, a Greek study showed that the outcomes of patients with Waldenström’s had not improved in the last decade despite of the advent of novel therapies such as rituximab and bortezomib. On the other hand, a larger Swedish study showed the survival of patients with Waldenström’s had improved in the last decade. Inspired on this apparent discrepancy, Bing Center investigators conducted the largest population-based study to date to identify survival trends in patients with Waldenström’s within the United States. The results of this study have been recently released in Blood, the journal of the American Society of Hematology.
May 17, 2014, Tampa, Florida: Nearly 300 patients and caregivers were present for the afternoon session in which Dr. Treon discussed the diagnostic and treatment implications of the MYD88 L265P and CXCR4 WHIM mutations that were discovered by the Bing Center for WM, and reported in two publications in BLOOD. Dr. Treon also discussed the results of the clinical trial with ibrutinib in WM patients, and the impact of CXCR4 mutations on response outcome.
The WM Macroglobulinemia Clinic at the DFCI is devoted to the care of patients with Waldenstrom's Macroglobulinemia and related IgM disorders, including IgM MGUS, Myeloma and Neuropathies.
For more information on the WM Clinic at DFCI, please visit the DFCI Center for Hematologic-Oncology/Waldenstrom's Macroglobulinemia Clinic.
Plasma cell regulatory pathways in WM. In recent studies, we have attempted to dissect the molecular mechanisms which prevent WM cells from fully differentiating into plasma cells. Ordinarily, B-cells mature in a defined manner passing through the mature B-cell stage to lymphoplasmacytic cells, and then onto mature plasma cells. Mature plasma cells make antibodies that serve to protect us against pathogens, and typically include the IgA and IgG antibodies.